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Generic prednisone tablets (2 g once daily) for one year. Patients were excluded if they had any other inflammatory (eg, lupus or multiple sclerosis) disease, had been taking any other immunosuppressant medication at the time of enrollment, used a beta or alpha blocker angiotensin-converting enzyme inhibitor, had hypertension, heart disease, hyperlipidemias, any organ transplant, or had received any corticosteroid immunosuppression therapy before enrollment. All patients who completed the trial were sent a randomization schedule which included five-week daily capsule dosage. For the first two weeks, all patients were on placebo capsules while undergoing follow-up examinations. The capsules were then rotated through three daily different doses of prednisone in the subsequent weeks. For last two weeks, all patients were on prednisone pills, taking one pill three times daily, with the same dose and frequency as prescribed previously. On the first day, dose of prednisone was titrated to target a maximum serum level of 5 ng/mL for men and 10 women. This was the beginning of a period "dosing maintenance," which continued for the duration of trial. In subsequent weeks, if levels of prednisone failed to drop at target, prednisone was titrated back up as dose-adjusted amounts were achieved. This "dosing correction" continued until the end of study (the second year follow-up). Participant, Investigator, and Care Provider Questionnaires Baseline assessments and questionnaires collected data on patient demographics, medical history, conditions, medications taken, and lifestyle preferences. The baseline assessment consisted of following 24 items: age, sex, body mass index, height, weight, health insurance coverage, educational level, and smoking history. Next, the baseline questionnaire asked following: In general, how frequently do you brush your teeth (besides having a dentist do it) and/or floss (and to which tooth), once a day, every or less than day; how often do you brush your teeth with a toothbrush and Prednisone 20mg $132.97 - $0.37 Per pill floss, once day, every or less than day; how often do you use toothpaste, mouthwash, mouthwash with fluoride, a mouth wash mint, or an antibiotic mouthwash; and if you use any medications to treat dental pain (eg, tricyclic antidepressants, oral contraceptives, antiemetics, corticosteroids), how often do you take them. The following information was collected for each patient after filling out the baseline questionnaire: current medications, number of and type. Patients completed the following questionnaire after a baseline examination and prednisone generic price on days 7, 9, 14, and 25 during pill-taking: At what time of day do you take your pills? How many pills per day do you take, on average? take any dietary supplements? How often do you have trouble swallowing pills? How many days per week do you take your pills? What frequency of oral sex do you participate in? If drink alcohol, how often do you have difficulty swallowing or if you get hangover, does it bother you? If you have a history of diabetes, what do you use as a "treatment" for your diabetes, and how often do you have trouble swallowing or if you get hangover, does it bother you? If you drink alcohol, how often do you have trouble swallowing or if you get hangover, does it bother you? The data on alcohol consumption were used to control for any other potential confounders. Patients who reported drinking alcohol but did not have a history of diabetes were removed from the analysis. Statistical Methods Differences in baseline characteristics between groups were examined using chi-square tests or Fisher exact tests. In the case where one or more pairs of variables was statistically significantly different at an alpha level of 0.05, a t test was used to compare differences between groups for each pair of groups. post hoc comparison, Fisher exact tests were used to compare differences in baseline characteristics among the groups. Data are presented as means ± SD, unless otherwise noted. To determine if a difference was significant, the Bonferroni correction applied to difference of the means. significance level used in this test is 0.05, although p values are reported when statistical significance is at the 5% level. Results Patients Eighty-seven enrolled patients were randomly assigned to one of the two treatment groups: prednisone (n = 66) or placebo 65). One patient in the placebo group withdrew prematurely because of a complication related to previous influenza infection. The final sample size involved 12 placebo-treated patients (3 female and 8 male). These patients were randomly assigned (1:1) to prednis.
Prednisone is used for treating severe allergies, arthritis, asthma, multiple sclerosis, and skin conditions.
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